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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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Preparation of polymeric microspheres as an ophthalmic drug delivery system for brimonidine tartrate

Couston, R. and McBride, E. and Wilson, C.G. (2009) Preparation of polymeric microspheres as an ophthalmic drug delivery system for brimonidine tartrate. Journal of Pharmacy and Pharmacology, 61 (S1). A22-A23. ISSN 0022-3573

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Abstract

A dramatic increase in the incidence of eye diseases, such as age-related macular degeneration, and inadequate therapeutic control has led to the search for advanced methods of sustained and targeted drug delivery. The development of polymeric devices, matrix implants and microspheres has facilitated the prolonged controlled release of therapies to the target sites. The aim of this study is to prepare brimonidine tartrate-loaded microspheres, which possess suitable characteristics for development into an implantable device that will later exploit the binding properties of ocular melanin to influence the release properties.