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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including those from the School of Psychological Sciences & Health - but also papers by researchers based within the Faculties of Science, Engineering, Humanities & Social Sciences, and from the Strathclyde Business School.

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Preparation of polymeric microspheres as an ophthalmic drug delivery system for brimonidine tartrate

Couston, R. and McBride, E. and Wilson, C.G. (2009) Preparation of polymeric microspheres as an ophthalmic drug delivery system for brimonidine tartrate. Journal of Pharmacy and Pharmacology, 61 (S1). A22-A23. ISSN 0022-3573

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Abstract

A dramatic increase in the incidence of eye diseases, such as age-related macular degeneration, and inadequate therapeutic control has led to the search for advanced methods of sustained and targeted drug delivery. The development of polymeric devices, matrix implants and microspheres has facilitated the prolonged controlled release of therapies to the target sites. The aim of this study is to prepare brimonidine tartrate-loaded microspheres, which possess suitable characteristics for development into an implantable device that will later exploit the binding properties of ocular melanin to influence the release properties.