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Spatial aspects of signalling by sphingosine 1-phosphate

Pyne, S. and Lee, S.C. and Long, J. and Gillies, L. and Pyne, N.J. (2009) Spatial aspects of signalling by sphingosine 1-phosphate. Naunyn-Schmiedeberg's Archives of Pharmacology, 380 (4). p. 369.

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Sphingosine kinase (SK) catalyses the phosphorylation of sphingosine to produce sphingosine 1-phosphate (S1P). S1P is a bioactive lipid that regulates cell proliferation, survival, migration etc. Extracellular S1P mediates its effects by binding to a family of five closely related G protein coupled receptors, S1P1-5. In addition, intracellular S1P may bind to undefined intracellular targets to elicit cellular responses. The focus of our recent work has

Item type: Article
ID code: 18951
Keywords: spatial aspect, s signalling, sphingosine 1-phosphate, Therapeutics. Pharmacology, Pharmacology
Subjects: Medicine > Therapeutics. Pharmacology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Strathprints Administrator
Date Deposited: 22 Jun 2010 08:55
Last modified: 21 May 2015 12:08

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