Pyne, S. and Lee, S.C. and Long, J. and Gillies, L. and Pyne, N.J. (2009) Spatial aspects of signalling by sphingosine 1-phosphate. Naunyn-Schmiedeberg's Archives of Pharmacology, 380 (4). p. 369. ISSN 0028-1298
Full text not available in this repository. (Request a copy from the Strathclyde author)Official URL: http://dx.doi.org/10.1007/s00210-009-0430-z
Abstract
Sphingosine kinase (SK) catalyses the phosphorylation of sphingosine to produce sphingosine 1-phosphate (S1P). S1P is a bioactive lipid that regulates cell proliferation, survival, migration etc. Extracellular S1P mediates its effects by binding to a family of five closely related G protein coupled receptors, S1P1-5. In addition, intracellular S1P may bind to undefined intracellular targets to elicit cellular responses. The focus of our recent work has
| Item type: | Article |
|---|---|
| ID code: | 18951 |
| Keywords: | spatial aspect, s signalling, sphingosine 1-phosphate, Therapeutics. Pharmacology |
| Subjects: | Medicine > Therapeutics. Pharmacology |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
| Related URLs: | |
| Depositing user: | Strathprints Administrator |
| Date Deposited: | 22 Jun 2010 09:55 |
| Last modified: | 02 May 2012 09:52 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/18951 |
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