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Open Access research that challenges the mind...

The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including those from the School of Psychological Sciences & Health - but also papers by researchers based within the Faculties of Science, Engineering, Humanities & Social Sciences, and from the Strathclyde Business School.

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Spatial aspects of signalling by sphingosine 1-phosphate

Pyne, S. and Lee, S.C. and Long, J. and Gillies, L. and Pyne, N.J. (2009) Spatial aspects of signalling by sphingosine 1-phosphate. Naunyn-Schmiedeberg's Archives of Pharmacology, 380 (4). p. 369.

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Abstract

Sphingosine kinase (SK) catalyses the phosphorylation of sphingosine to produce sphingosine 1-phosphate (S1P). S1P is a bioactive lipid that regulates cell proliferation, survival, migration etc. Extracellular S1P mediates its effects by binding to a family of five closely related G protein coupled receptors, S1P1-5. In addition, intracellular S1P may bind to undefined intracellular targets to elicit cellular responses. The focus of our recent work has