Strathprints Home | Open Access | Browse | Search | User area | Copyright | Help | Library Home | SUPrimo

The co-encapsulated antioxidant nanoparticles of ellagic acid and coenzyme Q10 ameliorate hyperlipidemia in high fat diet fed rats

Ratnam, D. and Chandraiah, G. and Meena, A. K. and Ramarao, P. and Kumar, M.N.V. Ravi (2009) The co-encapsulated antioxidant nanoparticles of ellagic acid and coenzyme Q10 ameliorate hyperlipidemia in high fat diet fed rats. Journal of Nanoscience and Nanotechnology, 9 (11). pp. 6741-6746. ISSN 1533-4880

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

Obesity is the major cause of type 2 diabetes with hyperlipidemia as one of its complications and antioxidants were found to be beneficial in such disease conditions. The present investigation is geared towards reduction of the dose required/improve the bioavailability of the combination of antioxidants, ellagic acid and coenzyme Q10 by co-encapsulating them into nanoparticles and study the possible synergism in ameliorating hyperlipidemia in high fat diet fed rats. The co-encapsulated particles at 10% (w/w of polymer) loading of ellagic acid and coenzyme Q10 have particle size of 260 nm. Male Sprague-Dawley (SD) rats on feeding high fat diet for over 4 weeks developed hyperlipidemia. The hyperlipidemic rats on 2 weeks post treatment with antioxidant combination administered as oral suspension or nanoparticles found to ameliorate the hyperlipidemic conditions and nanoparticles were found to be equally/more effective at 3 times lower dose in sustaining cholesterol lowering effect for extended periods, lowering glucose and triglycerides and in improving endothelial functioning, indicating the ability of the nanoparticles in improving efficacy of the duo. The results promise the potential of nanoparticles in improving the efficacy of ellagic acid and coenzyme Q10 in treating high fat diet induced hyperlipidemia in rats.

Item type: Article
ID code: 18944
Keywords: antioxidants, hyperlipidemia, nanoparticles, bioavailability, plga nanoparticles, diabetes-mellitus, reactive protein, statin therapy, oral delivery, in-vitro, cholesterol, nephrotoxicity, atorvastatin, cyclosporine, Internal medicine, Biology, Therapeutics. Pharmacology
Subjects: Medicine > Internal medicine
Science > Natural history > Biology
Medicine > Therapeutics. Pharmacology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 11 Jun 2010 10:15
    Last modified: 06 Dec 2013 22:49
    URI: http://strathprints.strath.ac.uk/id/eprint/18944

    Actions (login required)

    View Item