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Investigating the immunologic effects of cocr nanoparticles

Ogunwale, B. and Schmidt-Ott, A. and Meek, R.M.D. and Brewer, J.M. (2009) Investigating the immunologic effects of cocr nanoparticles. Clinical Orthopaedics and Related Research, 467 (11). pp. 3010-3016. ISSN 0009-921X

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Abstract

The increase in metal-on-metal hip arthroplasties has led to concern regarding the effect of raised serum and tissue metal ion levels. Our aim was to determine changes in the integrity and function of cells of the immune system after exposure to CoCr nanoparticles in specific cell culture experiments. Nanometer-sized particles of CoCr were made from a manufacturer's forged CoCr used for metal-on-metal articulations. Primary, murine dendritic cells and T and B lymphocytes then were exposed to these CoCr particles under cell culture conditions and then assayed for viability and proliferation/activation. CoCr nanoparticles did not directly activate dendritic cells or regulate B cells. Although nanoparticles were not directly toxic to resting T cells, Signals 1- and 2-dependent T cell proliferation were reduced. This may explain the observed reduction in CD8+ T cells observed in patients with metal-on-metal implants.

Item type: Article
ID code: 18937
Keywords: total hip replacements, cd4 t-cells, spark discharge, mckee-farrar, lymph-nodes, metal-ions, in-vitro, prostheses, chromium, antigen, Internal medicine, Microbiology, Orthopedics and Sports Medicine
Subjects: Medicine > Internal medicine
Science > Microbiology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
Depositing user: Strathprints Administrator
Date Deposited: 11 Jun 2010 11:57
Last modified: 05 Sep 2014 04:04
URI: http://strathprints.strath.ac.uk/id/eprint/18937

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