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From selection to caged aptamers: identification of light-dependent ssdna aptamers targeting cytohesin

Mayer, G. and Lohberger, A. and Butzen, S. and Pofahl, M. and Blind, M. and Heckel, A. (2009) From selection to caged aptamers: identification of light-dependent ssdna aptamers targeting cytohesin. Bioorganic and Medicinal Chemistry Letters, 19 (23). pp. 6561-6564.

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Abstract

Caged aptamers represent valuable tools for the spatiotemporal control of protein function by light. Here we describe a general route starting with the de novo selection process targeting cytohesin-1 and aiming at the synthesis of caged aptamers without the prior knowledge of detailed structural determinants of aptamer-target binding.

Item type: Article
ID code: 18897
Keywords: nucleic acids, aptamers, caged compounds, Pharmacy and materia medica, Biochemistry, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Molecular Biology, Clinical Biochemistry
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 20 May 2010 15:55
    Last modified: 05 Sep 2014 04:07
    URI: http://strathprints.strath.ac.uk/id/eprint/18897

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