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The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the Physical Activity for Health Group based within the School of Psychological Sciences & Health. Research here seeks to better understand how and why physical activity improves health, gain a better understanding of the amount, intensity, and type of physical activity needed for health benefits, and evaluate the effect of interventions to promote physical activity.

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From selection to caged aptamers: identification of light-dependent ssdna aptamers targeting cytohesin

Mayer, G. and Lohberger, A. and Butzen, S. and Pofahl, M. and Blind, M. and Heckel, A. (2009) From selection to caged aptamers: identification of light-dependent ssdna aptamers targeting cytohesin. Bioorganic and Medicinal Chemistry Letters, 19 (23). pp. 6561-6564.

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Abstract

Caged aptamers represent valuable tools for the spatiotemporal control of protein function by light. Here we describe a general route starting with the de novo selection process targeting cytohesin-1 and aiming at the synthesis of caged aptamers without the prior knowledge of detailed structural determinants of aptamer-target binding.