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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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From selection to caged aptamers: identification of light-dependent ssdna aptamers targeting cytohesin

Mayer, G. and Lohberger, A. and Butzen, S. and Pofahl, M. and Blind, M. and Heckel, A. (2009) From selection to caged aptamers: identification of light-dependent ssdna aptamers targeting cytohesin. Bioorganic and Medicinal Chemistry Letters, 19 (23). pp. 6561-6564.

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Abstract

Caged aptamers represent valuable tools for the spatiotemporal control of protein function by light. Here we describe a general route starting with the de novo selection process targeting cytohesin-1 and aiming at the synthesis of caged aptamers without the prior knowledge of detailed structural determinants of aptamer-target binding.