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A pharmacoscintigraphic study of three time-delayed capsule formulations in healthy male volunteers

McConville, Jason T. and Hodges, Lee Ann and Jones, Tamara and Band, Janet P. and O'Mahony, Bridget and Lindsay, Blythe and Ross, Alistair C. and Florence, Alastair J. and Stanley, Adrian J. and Humphrey, Michael J. and Wilson, Clive and Stevens, Howard (2009) A pharmacoscintigraphic study of three time-delayed capsule formulations in healthy male volunteers. Journal of Pharmaceutical Sciences, 98 (11). pp. 4251-4263. ISSN 0022-3549

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Abstract

Three time-delayed capsule (TDC) formulations were investigated in a pharmacoscintigraphic study, using a three-way crossover design in eight healthy male volunteers. Additionally, the pulsed release of a TDC was investigated with time-lapse photography, using a nondisintegrating riboflavin tablet. The photographic study indicated how the release characteristics of the TDC relied on the erosion of a tablet containing hypromellose (HPMC). Each TDC was duel radio labelled with indium-111 and technetium-99 m DTPA complexes, to observe drug release scintigraphically (theophylline was a marker compound). Three formulations, having in vitro dissolution release times of 1.8, 2.9 or 4.0 h were shown to compare favourably with mean in vivo scintigraphic release times of 2.7, 3.0 and 4.0 h for each formulation containing 20, 24 or 35% (w/w) HPMC concentrations respectively. An increase in HPMC concentration was associated with a delayed technetium release time, and followed the same rank order as the in vitro dissolution study. Observed radiolabel dispersion always occurred in the small intestine. In conclusion, the study established that the TDC performs and demonstrates an in vitro-in vivo correlation. Additionally, time and site of release were accurately visualized by gamma scintigraphy, and confirmed with determination of theophylline absorption.

Item type: Article
ID code: 18893
Notes: Strathprints' policy is to record up to 8 authors per publication, plus any additional authors based at the University of Strathclyde. More authors may be listed on the official publication than appear in the Strathprints' record.
Keywords: controlled delivery, gastrointestinal transit, scintigraphy, site-specific delivery, targeted drug delivery, Pharmacy and materia medica, Pharmaceutical Science
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences > Pharmaceutical Sciences
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 20 May 2010 14:28
    Last modified: 28 Mar 2014 05:22
    URI: http://strathprints.strath.ac.uk/id/eprint/18893

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