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Improving platinum(II)-based anticancer drug delivery using cucurbit[n]urils

Wheate, N.J. (2008) Improving platinum(II)-based anticancer drug delivery using cucurbit[n]urils. Journal of Inorganic Biochemistry, 102 (12). pp. 2060-2066. ISSN 0162-0134

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Abstract

Despite the synthesis of hundreds of new platinum(II) and platinum(IV)-based complexes each year as potential anticancer drugs, only three have received world-wide approval: cisplatin, carboplatin and oxaliplatin. The next big advance in platinum-based chemotherapy is not likely to come from the development of new drugs, but from the controlled and targeted delivery of already approved drugs or those in late stage clinical trials. Encapsulation of platinum drugs inside macromolecules has already demonstrated promise, and encapsulation within cucurbit[n]urils has shown particular potential. Partial or full encapsulation within cucurbit[n]urils provides steric hindrance to drug degradation by peptides and proteins, and the use of different sized cucurbit[n]urils allows for the tuning of drug release rates, cytotoxicity and toxicity.

Item type: Article
ID code: 18860
Notes: http://suprimo.lib.strath.ac.uk/primo_library/libweb/action/display.do?ct=display&doc=SUSFX954925478535&indx=1&frbg=&dum=true&vid=SUVU01&vl(54032236UI0)=lsr02&vl(96071691UI1)=all_items&srt=rank&indx=1&dstmp=1274087493379&tab=local&ct=search&scp.scps=scope%3A(SU)&vl(freeText0)=Journal%20of%20Inorganic%20Biochemistry&fn=search&mode=Basic&dscnt=0
Keywords: Platinum, Cucurbituril, Cancer, Drug delivery, cytotoxicity, toxicity, cisplatin, oxaliplatin, BBR3464, BBR3571, Therapeutics. Pharmacology, Pharmacy and materia medica, Microbiology, Biochemistry, Inorganic Chemistry
Subjects: Medicine > Therapeutics. Pharmacology
Medicine > Pharmacy and materia medica
Science > Microbiology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Ms Ann Barker-Myles
    Date Deposited: 17 May 2010 10:01
    Last modified: 05 Sep 2014 02:02
    URI: http://strathprints.strath.ac.uk/id/eprint/18860

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