Wheate, N.J. (2008) Improving platinum(II)-based anticancer drug delivery using cucurbit[n]urils. Journal of Inorganic Biochemistry, 102 (12). pp. 2060-2066. ISSN 0162-0134
Full text not available in this repository. (Request a copy from the Strathclyde author)Abstract
Despite the synthesis of hundreds of new platinum(II) and platinum(IV)-based complexes each year as potential anticancer drugs, only three have received world-wide approval: cisplatin, carboplatin and oxaliplatin. The next big advance in platinum-based chemotherapy is not likely to come from the development of new drugs, but from the controlled and targeted delivery of already approved drugs or those in late stage clinical trials. Encapsulation of platinum drugs inside macromolecules has already demonstrated promise, and encapsulation within cucurbit[n]urils has shown particular potential. Partial or full encapsulation within cucurbit[n]urils provides steric hindrance to drug degradation by peptides and proteins, and the use of different sized cucurbit[n]urils allows for the tuning of drug release rates, cytotoxicity and toxicity.
| Item type: | Article |
|---|---|
| ID code: | 18860 |
| Notes: | http://suprimo.lib.strath.ac.uk/primo_library/libweb/action/display.do?ct=display&doc=SUSFX954925478535&indx=1&frbg=&dum=true&vid=SUVU01&vl(54032236UI0)=lsr02&vl(96071691UI1)=all_items&srt=rank&indx=1&dstmp=1274087493379&tab=local&ct=search&scp.scps=scope%3A(SU)&vl(freeText0)=Journal%20of%20Inorganic%20Biochemistry&fn=search&mode=Basic&dscnt=0 |
| Keywords: | Platinum, Cucurbituril, Cancer, Drug delivery, cytotoxicity, toxicity, cisplatin, oxaliplatin, BBR3464, BBR3571, Therapeutics. Pharmacology, Pharmacy and materia medica, Microbiology |
| Subjects: | Medicine > Therapeutics. Pharmacology Medicine > Pharmacy and materia medica Science > Microbiology |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
| Related URLs: | |
| Depositing user: | Ms Ann Barker-Myles |
| Date Deposited: | 17 May 2010 10:01 |
| Last modified: | 12 Mar 2012 11:11 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/18860 |
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