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Combined treatment of biomatrices with nisin and pulsed electric fields as a potential decontamination method?

Griffiths, S. and Maclean, M. and MacGregor, S.J. and Anderson, J.G. and Grant, M.H. (2009) Combined treatment of biomatrices with nisin and pulsed electric fields as a potential decontamination method? European Cells and Materials, 18 (Suppl.). p. 18. ISSN 1473-2262

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Abstract

Pulsed electric field (PEF) treatment has been shown to achieve bacterial inactivation in collagen gels whilst retaining the ability of the collagen to function as a biomaterial [1, 2]. Nisin, an antimicrobial peptide, has been used widely as a food preservative and has shown bactericidal action against a number of Gram-positive bacteria [3]. The potential of nisin to increase the efficacy of PEF disinfection of collagen gels to be used for tissue engineering applications was investigated.