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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including those from the School of Psychological Sciences & Health - but also papers by researchers based within the Faculties of Science, Engineering, Humanities & Social Sciences, and from the Strathclyde Business School.

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Can blood flow in the bone be measured using coloured labelled Microspheres?

Ghazzawi, H. and Abouel-Enin, S. and Reichert, I. and Gourlay, T. (2009) Can blood flow in the bone be measured using coloured labelled Microspheres? Internet Journal of Laboratory Medicine, 3 (2). ISSN 1937-8181

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Abstract

This study was designed to determine whether coloured micro-spheres represent a realistic alternative to more conventional techniques for the assessment of bone blood flow (BBF). BBF is normally measured using radioactive labelled micro-spheres, a technique that is accurate, but becoming increasingly challenged for safety and environmental reasons. Coloured micro-spheres come in two varieties, dye-fixed and dye eluting, and both have been employed for the measurement of blood flow in soft tissue for some time. However, measuring blood flow in bone presents a different challenge to that of soft tissue, insofar as the bone has to be dissolved using harsh chemicals to enable the harvesting of the micro-spheres for counting. This study therefore was designed to determine whether these micro-spheres would survive the harvesting process, and whether they could be identified and counted afterwards.