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On the blockade of acetylcholine release at mouse motor nerve terminals by beta-bungarotoxin and crotoxin

Rowan, E.G. and Pemberton, K.E. and Harvey, Alan L. (1990) On the blockade of acetylcholine release at mouse motor nerve terminals by beta-bungarotoxin and crotoxin. British Journal of Pharmacology, 100 (2). pp. 301-304. ISSN 0007-1188

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Abstract

1. beta-Bungarotoxin and crotoxin are phospholipose A2 neurotoxins, which block irreversibly the evoked release of acetylcholine from motor nerve terminals of mouse triangularis sterni preparations. 2. Extracellular recording of nerve terminal action potentials reveal that inhibition of transmitter release is not associated with failure of the action potential to invade nerve terminals. 3. When evoked transmitter release (measured as intracellularly recorded endplate potentials) was blocked by beta-bungarotoxin, spontaneous acetylcholine release was stimulated as in control experiments by K(+)-induced depolarization and by the Ca2(+)-ionophore A23187. 4. The site of action of the toxins remains to be elucidated but would appear to be associated with the coupling of action potential induced-depolarization to the release mechanism, rather than with the release mechanism itself.

Item type: Article
ID code: 18529
Keywords: acetylcholine release, motor nerve terminals, beta-bungarotoxin, crotoxin, Pharmacy and materia medica, Pharmacology
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Dr EG Rowan
    Date Deposited: 17 Nov 2010 11:48
    Last modified: 05 Sep 2014 00:37
    URI: http://strathprints.strath.ac.uk/id/eprint/18529

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