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Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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Determination of the strain-dependent hydraulic permeability of the compressed bovine nucleus pulposus

Heneghan, P. and Riches, P.E. (2008) Determination of the strain-dependent hydraulic permeability of the compressed bovine nucleus pulposus. Journal of Biomechanics, 41 (4). pp. 903-906. ISSN 0021-9290

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Abstract

The hydraulic permeability, k, of the nucleus pulposus (NP) is crucial, both in withstanding compressive stress and for convective transport of nutrients within the disc. Permeability has previously been determined using biphasic mathematical models, but has not been found by direct permeation experiments, which is the objective of this study. Bovine coccygeal nucleus samples (n=64), φ10mm and thickness 683±49μm (mean±S.D.) were compressed axially to one of λ=1.0, 0.9, 0.8, 0.7, 0.6, 0.5, 0.4 or 0.3, where λ is the stretch ratio. Ringer's solution was permeated through the sample, with an o-ring ensuring axial flow. During stress equilibrium, k was determined and fitted to four permeability-strain equations. Values of k were comparable to those arising from mathematical models, lending confidence to permeability being determined from such models.