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Clinical observations associated with proven and unproven cases in the ESCRS study of prophylaxis of postoperative endophthalmitis after cataract surgery

Barry, P. and Gardner, S. and Seal, D. and Gettinby, G. and Lees, F. and Peterson, M. and Revie, C.W. and , ESCRS Endophthalmitis Study Group (2009) Clinical observations associated with proven and unproven cases in the ESCRS study of prophylaxis of postoperative endophthalmitis after cataract surgery. Journal of Cataract and Refractive Surgery, 35 (9). pp. 1523-1531. ISSN 0886-3350

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    Abstract

    Aims to describe cases of postoperative endophthalmitis in the European Society of Cataract and Refractive Surgeons (ESCRS) study of the prophylaxis of endophthalmitis, compare characteristics of unproven cases and cases proven by culture or polymerase chain reaction, and compare the characteristics with those in other reported series. Twenty-four ophthalmology units in Austria, Belgium, Germany, Italy, Poland, Portugal, Spain, Turkey, and the United Kingdom. Univariable and multivariable logistic regression models were used to analyze data for statistical association of signs and symptoms in cases with proven or unproven endophthalmitis. Specific data describing characteristics of the cases were compared between the 2 types of cases. Data from 29 endophthalmitis cases were analyzed. Swollen lids and pain were statistically associated with proven cases of endophthalmitis on univariable regression analysis. Multivariable analysis indicated that swollen lids and an opaque vitreous were associated with proven cases. Five cases of endophthalmitis occurred in the cefuroxime-treated groups. No case of streptococcal infection occurred in the cefuroxime-treated groups. However, cases of infection due to streptococci showed striking differences in visual acuity and were associated with earlier onset. Characteristics in the 29 cases parallel results in previous studies, such as the Endophthalmitis Vitrectomy Study, although the addition of a control group in the ESCRS study elicited additional findings. Swollen lids, pain, and an opaque vitreous were statistically associated with proven endophthalmitis cases in the ESCRS study.

    Item type: Article
    ID code: 18407
    Keywords: postoperative endophthalmitis, cataract surgery, multivariate analysis, prophylaxis, Medicine (General), Mathematics, Ophthalmology, Surgery, Sensory Systems
    Subjects: Medicine > Medicine (General)
    Science > Mathematics
    Department: Faculty of Science > Mathematics and Statistics
    Faculty of Science > Mathematics and Statistics > Statistics and Modelling Science
    Faculty of Science > Computer and Information Sciences
    Related URLs:
      Depositing user: Mrs Ann Lynch
      Date Deposited: 25 Mar 2010 09:43
      Last modified: 06 Sep 2014 00:06
      URI: http://strathprints.strath.ac.uk/id/eprint/18407

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