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Inhibition of cell growth and glutathione depletion by calcium channel blockers

Akbar, M. and Henderson, C.J. and Grant, M. Helen (2008) Inhibition of cell growth and glutathione depletion by calcium channel blockers. Toxicology, 253 (1-3). pp. 14-15. ISSN 0300-483X

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Abstract

Many in vitro studies have shown that calcium channel blockers (CCBs) inhibit cell proliferation (Sachinidis et al., 1992). Vascular smooth muscle cell proliferation is the primary cause of angioplasty stent and synthetic bypass graft failure through restenosis. Coating such devices with calcium channel blockers to inhibit proliferation may provide a delivery platform to minimise restenosis. This study compared the effects of three CCBs on cell growth assessing their toxicity and thus suitability as coatings for stents.