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The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including by researchers from the Department of Computer & Information Sciences involved in mathematically structured programming, similarity and metric search, computer security, software systems, combinatronics and digital health.

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Uptake of Cr (VI) and Cr (III)-GSH complex across rat liver cell nuclei

Raghunathan, V.K. and Tettey, J.N.A. and Grant, M.H. (2008) Uptake of Cr (VI) and Cr (III)-GSH complex across rat liver cell nuclei. Toxicology, 253 (1-3). pp. 20-21. ISSN 0300-483X

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Abstract

Cr (VI) is a known carcinogen that readily crosses the cellular membrane and is then reduced by intracellular reductants such as reduced glutathione (GSH) to Cr (III), forming various reactive intermediate compounds (Ding and Shi, 2002). The interaction of Cr (VI) and GSH is known to be one of the causes of DNA damage in vitro (Mazzer et al., 2007). This study investigates the occurrence of Cr (III)-GSH in freshly isolated rat hepatocytes incubated with Cr (VI), and the uptake of Cr (VI) and Cr (III)-GSH complex across rat liver cell nuclei. Cr (III)-GSH complex was synthesised by the method of Levina et al. (2003), and its formation confirmed by liquid chromatography-mass spectrometry (LC-MS).