Rowan, E.G. and Harvey, A.L. (1996) Toxins affecting k+ channels. Brazilian Journal of Medical and Biological Research, 29 (12). pp. 1765-1780. ISSN 0100-879XFull text not available in this repository. (Request a copy from the Strathclyde author)
Potassium channels are involved in modulating the excitability of neurones by regulating the membrane potential, or by affecting the amount of neurotransmitter released from nerve terminals. Potassium channels are highly diverse and can be activated by either voltage or increased intracellular calcium concentration. The potassium channel forms a highly selective membrane pore. Four subunits each with six membrane-spanning regions (S1-S6) are required to produce a functional pore. Molecular biologists have cloned more than 50 different potassium channel subtypes. Naturally occurring protein toxins have been used to pharmacologically characterize native and cloned potassium channels.
|Keywords:||voltage-dependent potassium channels, calcium-dependent potassium channels, potassium channel toxins, neuropharmacology, molecular pharmacology, Pharmacy and materia medica, Biochemistry, Neuroscience(all), Cell Biology, Immunology, Pharmacology, Toxicology and Pharmaceutics(all), Biophysics, Physiology, Medicine(all)|
|Subjects:||Medicine > Pharmacy and materia medica|
|Department:||Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences|
|Depositing user:||Strathprints Administrator|
|Date Deposited:||25 Mar 2010 18:19|
|Last modified:||27 Apr 2016 14:21|