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Melphalan and urinary estrogens

Anderson, J.M. and Grant, J.K. and Gettinby, G. (1979) Melphalan and urinary estrogens. British Journal of Cancer, 40 (2). pp. 314-315. ISSN 0007-0920

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A test of the concept of chemical suppression of ovarian function by cytotoxic drugs previously reported (Anderson et al., 1978, Br. J. Cancer, 37, 477) revealed no supportive evidence from follicular and luteal-phase measurements of plasma oestradiol (E2) in 6 premenopausal women prescribed repeated 5-day courses of melphalan after mastectomy for cancer. To circumvent the difficulties of frequent repeated blood sampling, 3 of these patients were studied in greater depth.