Picture of athlete cycling

Open Access research with a real impact on health...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the Physical Activity for Health Group based within the School of Psychological Sciences & Health. Research here seeks to better understand how and why physical activity improves health, gain a better understanding of the amount, intensity, and type of physical activity needed for health benefits, and evaluate the effect of interventions to promote physical activity.

Explore open research content by Physical Activity for Health...

Neuromuscular effects of nigexine, a basic phospholipase-a2 from naja-nigricollis venom

Rowan, E.G. and Harvey, A.L. and Menez, A. (1991) Neuromuscular effects of nigexine, a basic phospholipase-a2 from naja-nigricollis venom. Toxicon, 29 (3). pp. 371-374. ISSN 0041-0101

Full text not available in this repository. Request a copy from the Strathclyde author

Abstract

Nigexine is a basic phospholipase A2 from the venom of the spitting cobra Naja nigricollis. In addition to its anticoagulant and cytolytic properties, nigexine also affects neuromuscular transmission in vitro. On chick biventer cervicis preparations, 1.5 μM nigexine caused a slowly developing block of responses to nerve stimulation, and a progressive loss of postjunctional sensitivity. Nigexine was at least 10 times less potent than notexin. On frog cutaneous pectoris preparations, nigexine caused a transient facilitation of evoked acetylcholine release, followed by a block. Spontaneous release was not abolished, and nigexine induced the release of abnormally large packets of transmitter. Nigexine also caused contracture of muscle fibres, accompanied by depolarization and degeneration. Nigexine appears to be able to cause prejunctional blockade and direct muscle damage to isolated skeletal muscle preparations.