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Amino acid sequence of a muscarinic toxin deduced from the cDNA nucleotide sequence

Ducancel, F. and Rowan, E.G. and Cassar, E. and Harvey, A.L. and Menez, A. and Boulain, J.C. (1991) Amino acid sequence of a muscarinic toxin deduced from the cDNA nucleotide sequence. Toxicon, 29 (4-5). pp. 516-520. ISSN 0041-0101

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Abstract

We prepared a cDNA library from venom glands of the green mamba Dendroaspis angusticeps. A cDNA clone was isolated using an appropriate nucleotide probe. The nucleotide sequence codes for a 21 residue signal peptide followed by a 65 residue protein having the amino acid sequence of muscarinic toxin 2, as confirmed in the accompanying paper (Karlsson, E., Risinger, C., Jolkkonen, M., Wernstedt, C. and Adem, A.). The cDNA encoding the muscarinic toxin has been compared with those encoding other snake toxins. There are close similarities with short-chain curaremimetic neurotoxins.

Item type: Article
ID code: 17735
Keywords: cDNA nucleotide sequence, Dendroaspis angusticeps, venom glands, muscarinic toxin, Genetics, Pharmacy and materia medica, Toxicology
Subjects: Science > Natural history > Genetics
Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
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    Depositing user: Strathprints Administrator
    Date Deposited: 11 May 2010 19:10
    Last modified: 05 Sep 2014 00:38
    URI: http://strathprints.strath.ac.uk/id/eprint/17735

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