Strathprints logo
Strathprints Home | Open Access | Browse | Search | User area | Copyright | Help | Library Home | SUPrimo

The effects of Indian red scorpion Buthus tamulus venom in vivo and in vitro

Rowan, E.G. and Vatanpour, H. and Furman, B.L. and Harvey, A.L. and Tanira, M.O.M. and Gopalakrishnakone, P. (1992) The effects of Indian red scorpion Buthus tamulus venom in vivo and in vitro. Toxicon, 30 (10). pp. 1157-1164. ISSN 0041-0101

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

The Indian red scorpion Buthus tamulus (or Mesobuthus tamulus) can cause fatal envenoming, but its mechanism of action is unclear. Venom was tested in vivo in anaesthetized rats and in vitro on isolated cardiac and skeletal muscle preparations. In vivo, the venom caused marked rhythmical fluctuations in blood pressure preceding cardiovascular collapse and death. On sheep Purkinje fibres, venom could induce spontaneous action potentials and cause prolongation of action potential duration. In chick biventer cervicis and mouse triangularis sterni preparations, venom enhanced the release of acetylcholine and induced repetitive firing of nerve action potentials in response to single shock stimulation. High concentrations caused stimulation then block of neuromuscular transmission. The main effects of Buthus tamulus venom are likely to be due to toxins that affect the opening of Na+ channels in nerves and muscles. This will cause an increase in the release of neurotransmitters in the peripheral nervous system, which may produce cardiovascular abnormalities and respiratory paralysis.

Item type: Article
ID code: 17717
Keywords: Buthus tamulus, venom, scorpion, cardiovascular abnormalities, respiratory paralysis, Zoology, Pharmacy and materia medica, Toxicology
Subjects: Science > Zoology
Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 12 May 2010 20:27
    Last modified: 05 Sep 2014 00:41
    URI: http://strathprints.strath.ac.uk/id/eprint/17717

    Actions (login required)

    View Item