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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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Some statistical considerations in the analysis of case-control studies when the exposure variables are continuous measurements

Robertson, C. and Boyle, P. and Hsieh, C.C. and MacFarlane, G.J. and Maisonneuve, P. (1994) Some statistical considerations in the analysis of case-control studies when the exposure variables are continuous measurements. Epidemiology, 5 (2). pp. 164-170. ISSN 1044-3983

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Abstract

This paper focuses on some statistical considerations in the estimation of dose response in case control studies when the exposure variables are continuous measurements. The first point is that the-effects of differential variability in the exposure distributions over cases and controls cannot be differentiated from a true quadratic risk model. The second point is that when dealing with variables where zero denotes no exposure, it is important to treat the unexposed subjects separately from those who were exposed. Failure to do so can lead to differential variability among cases and controls and the resulting confounding with a quadratic risk model. Both of these points are illustrated by an example.