Picture of scraped petri dish

Scrape below the surface of Strathprints...

The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs. Explore world class Open Access research by researchers at Strathclyde, a leading technological university.

Explore

Some statistical considerations in the analysis of case-control studies when the exposure variables are continuous measurements

Robertson, C. and Boyle, P. and Hsieh, C.C. and MacFarlane, G.J. and Maisonneuve, P. (1994) Some statistical considerations in the analysis of case-control studies when the exposure variables are continuous measurements. Epidemiology, 5 (2). pp. 164-170. ISSN 1044-3983

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

This paper focuses on some statistical considerations in the estimation of dose response in case control studies when the exposure variables are continuous measurements. The first point is that the-effects of differential variability in the exposure distributions over cases and controls cannot be differentiated from a true quadratic risk model. The second point is that when dealing with variables where zero denotes no exposure, it is important to treat the unexposed subjects separately from those who were exposed. Failure to do so can lead to differential variability among cases and controls and the resulting confounding with a quadratic risk model. Both of these points are illustrated by an example.