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Some statistical considerations in the analysis of case-control studies when the exposure variables are continuous measurements

Robertson, C. and Boyle, P. and Hsieh, C.C. and MacFarlane, G.J. and Maisonneuve, P. (1994) Some statistical considerations in the analysis of case-control studies when the exposure variables are continuous measurements. Epidemiology, 5 (2). pp. 164-170. ISSN 1044-3983

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Abstract

This paper focuses on some statistical considerations in the estimation of dose response in case control studies when the exposure variables are continuous measurements. The first point is that the-effects of differential variability in the exposure distributions over cases and controls cannot be differentiated from a true quadratic risk model. The second point is that when dealing with variables where zero denotes no exposure, it is important to treat the unexposed subjects separately from those who were exposed. Failure to do so can lead to differential variability among cases and controls and the resulting confounding with a quadratic risk model. Both of these points are illustrated by an example.

Item type: Article
ID code: 17688
Keywords: logistic regression, differential variability, nonexposure, dose response, case control studies, models, data analysis, Statistics, Epidemiology
Subjects: Social Sciences > Statistics
Department: Faculty of Science > Mathematics and Statistics
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Depositing user: Strathprints Administrator
Date Deposited: 10 May 2010 12:06
Last modified: 05 Sep 2014 00:45
URI: http://strathprints.strath.ac.uk/id/eprint/17688

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