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Alteration of the erythrocyte glutathione redox balance by N-acetylcysteine, captopril and exogenous glutathione

Russell, J. and Spickett, C.M. and Reglinski, J. and Smith, W.E. and McMurray, J.J.V. and Abdullah, I.B. (1994) Alteration of the erythrocyte glutathione redox balance by N-acetylcysteine, captopril and exogenous glutathione. FEBS Letters, 347 (2-3). pp. 215-220. ISSN 0014-5793

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Abstract

The effect of the thiol containing compounds N-acetylcysteine and captopril on glutathione metabolism in human erythrocytes has been investigated non-invasively using 1H spin echo NMR. N-Acetylcysteine was found to increase the reduced form of glutathione while captopril increased the oxidized form, but no changes in the total glutathione concentration were observed. Incubation of the cells with buthionine sulphoximine to inhibit de novo glutathione synthesis did not affect the response. The results show that these compounds act by altering the redox balance of glutathione rather than by stimulating its synthesis, and that their mechanisms of action are different, and not simply due to the presence of the thiol group.

Item type: Article
ID code: 17680
Keywords: NMR, antioxidant defense, glutathione, N-acetylcysteine, captopril, human erythrocyte, Pharmacy and materia medica, Biochemistry, Structural Biology, Cell Biology, Genetics, Molecular Biology, Biophysics
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Science > Pure and Applied Chemistry
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    Depositing user: Strathprints Administrator
    Date Deposited: 09 May 2010 14:49
    Last modified: 05 Sep 2014 00:46
    URI: http://strathprints.strath.ac.uk/id/eprint/17680

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