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The pharmacological effects of cadmium on skeletal neuromuscular-transmission

Braga, M.F.M. and Rowan, E.G. (1994) The pharmacological effects of cadmium on skeletal neuromuscular-transmission. General pharmacology, 25 (8). pp. 1729-1739. ISSN 0306-3623

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Abstract

1. 1. Cadmium (100 μ M) blocks neuromuscular transmission by blocking prejunctional voltage dependent calcium channels in a competitive manner. 2. 2. Prolonged exposure to cadmium leads to a block of neuromuscular transmission that is not competitive. 3. 3. Cadmium can increase the spontaneous release of acetylcholine, this release is modified by the cation composition of the bathing solution. 4. 4. Cadmium may enter the nerve terminal via the voltage dependent calcium channels (the L-type calcium channel has been implicated) and exert some of its actions intracellularly. 5. 5. All of the extracellular effects of cadmium can be reversed by cysteine.

Item type: Article
ID code: 17665
Keywords: cadmium, neuromuscular transmission, calcium channels, cysteine, Pharmacy and materia medica
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 07 May 2010 11:12
    Last modified: 12 Mar 2012 11:08
    URI: http://strathprints.strath.ac.uk/id/eprint/17665

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