Strathprints Home | Open Access | Browse | Search | User area | Copyright | Help | Library Home | SUPrimo

This histamine-like effects of Phallusia nigra extract: evidences for direct activity at H1 receptors

Costa, L.V. and Malpezzi, E.L.A. and Berlinck, R.G.S. and Rowan, E.G. and deFreitas, J.C. (1997) This histamine-like effects of Phallusia nigra extract: evidences for direct activity at H1 receptors. Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology, 117 (1). pp. 111-115. ISSN 1367-8280

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

The methanol extract (mol. wt lower than 3,000 Da) of the sea squirt Phallusia nigra has stimulatory activity on guinea-pig ileum preparations. This effect was inhibited by cyproheptadine and mepyramine, but not by atropine. Mepyramine antagonized competitively the extract activity with a pA2 of 10.09 ± 1.12, suggesting a direct activity on H1 histamine receptors. The extract was also assayed on guinea-pig right atria, however, only a mild increase in spontaneous contractions was observed compared to histamine, showing that the extract was a rather poor activator of cardiac H2 receptors. Histamine was not detected upon TLC analysis of the extract by comparison with an authentic standard.

Item type: Article
ID code: 17599
Keywords: Phallusia nigra, tunicates, histamine agonist, histamine receptors, mepyramine, competitive antagonism, guinea pig ileum, guinea pig right atria, Pharmacy and materia medica, Microbiology
Subjects: Medicine > Pharmacy and materia medica
Science > Microbiology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 13 May 2010 20:12
    Last modified: 04 Oct 2012 12:56
    URI: http://strathprints.strath.ac.uk/id/eprint/17599

    Actions (login required)

    View Item