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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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This histamine-like effects of Phallusia nigra extract: evidences for direct activity at H1 receptors

Costa, L.V. and Malpezzi, E.L.A. and Berlinck, R.G.S. and Rowan, E.G. and deFreitas, J.C. (1997) This histamine-like effects of Phallusia nigra extract: evidences for direct activity at H1 receptors. Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology, 117 (1). pp. 111-115. ISSN 1367-8280

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Abstract

The methanol extract (mol. wt lower than 3,000 Da) of the sea squirt Phallusia nigra has stimulatory activity on guinea-pig ileum preparations. This effect was inhibited by cyproheptadine and mepyramine, but not by atropine. Mepyramine antagonized competitively the extract activity with a pA2 of 10.09 ± 1.12, suggesting a direct activity on H1 histamine receptors. The extract was also assayed on guinea-pig right atria, however, only a mild increase in spontaneous contractions was observed compared to histamine, showing that the extract was a rather poor activator of cardiac H2 receptors. Histamine was not detected upon TLC analysis of the extract by comparison with an authentic standard.