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The genetic basis of resistance to ostertagia circumcincta in lambs

Stear, M.J. and Bairden, K. and Bishop, S.C. and Buitkamp, J. and Duncan, J.L. and Gettinby, G. and McKellar, Q.A. and Park, M. (1997) The genetic basis of resistance to ostertagia circumcincta in lambs. Veterinary Journal, 154 (2). pp. 111-119. ISSN 1090-0233

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Abstract

The relationship between Ostertagia (Teladorsagia) circumcincta and sheep is one of the best understoodhost-parasite relationships in any species. The key components of resistance have been quantified, the extent of genetic control has been established for lambs, and methods now exist to breed lambs which will be both more resistant to worms and more productive than unselected lambs. A major gene for resistance has been identified within or around the major histocompatibility complex, and this gene appears to be the strongest yet identified for resistance to any parasite species. The most important mechanisms of resistance are local IgA responses which regulate worm fecundity and immediate hypersensitivity responses which regulate worm burdens. IgA responses develop before effective immediate hypersensitivity responses. Good simulation models now exist to predict, for example, outbreaks of disease and the response of sheep to selection. The challenge now is to use our improved understanding of the population biology to develop even better simulation models and to produce expert systems based on these models which can be used by veterinarians and others to determine optimal procedures for individual farms to control disease and reduce sub-clinical economic losses.

Item type: Article
ID code: 17590
Notes: Strathprints' policy is to record up to 8 authors per publication, plus any additional authors based at the University of Strathclyde. More authors may be listed on the official publication than appear in the Strathprints' record.
Keywords: parasite, genetics, sheep, immunity, epidemiology, Animal culture, Probabilities. Mathematical statistics, veterinary(all), Animal Science and Zoology
Subjects: Agriculture > Animal culture
Science > Mathematics > Probabilities. Mathematical statistics
Department: Faculty of Science > Mathematics and Statistics
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 14 May 2010 14:11
    Last modified: 05 Sep 2014 00:58
    URI: http://strathprints.strath.ac.uk/id/eprint/17590

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