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Purification of a 5-ht uptake inhibitor from the venom of cerastes vipera

Alzahaby, M. and Harvey, A.L. and Young, L.C. and Faure, G. and Rowan, E.G. (1998) Purification of a 5-ht uptake inhibitor from the venom of cerastes vipera. Toxicon, 36 (4). pp. 601-607. ISSN 0041-0101

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Abstract

A protein that inhibits the re-uptake of 5-hydroxytryptamine into rat brain synaptosomes was isolated from the venom of the Sahara sand viper (Cerastes vipera) by gel filtration and reverse phase chromatography. It has a molecular weight of 13 739 Da and an 50 of about 50 nM for blocking uptake of 3H-5-HT into rat brain synaptosomes. It also augmented the responses to 5-HT in a smooth muscle preparation. It has phospholipase A2 activity, but it has no lytic activity as measured by its inability to release lactate dehydrogenase from rat brain synaptosomes. Determination of the N-terminal sequence revealed a similarity with a phospholipase A2 previously isolated from Cerastes cerastes venom.