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The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the Physical Activity for Health Group based within the School of Psychological Sciences & Health. Research here seeks to better understand how and why physical activity improves health, gain a better understanding of the amount, intensity, and type of physical activity needed for health benefits, and evaluate the effect of interventions to promote physical activity.

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H-1 nmr as a non-invasive probe of amniotic fluid in insulin dependant diabetes mellitus

McGowan, P.E. and Lawrie, W.C. and Reglinski, J. and Spickett, C.M. and Wilson, R. and Walker, J.J. and Wisdom, S. and MacLean, M.A. (1999) H-1 nmr as a non-invasive probe of amniotic fluid in insulin dependant diabetes mellitus. Journal of Perinatal Medicine, 27 (5). pp. 404-408.

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Abstract

Ten amniotic fluid samples obtained from third trimester pregnant women suffering from insulin dependant diabetes mellitus were analysed by 1H-NMR and compared to ten samples from a group of normal volunteers. A subset of the metabolites identified; valine, lactate, alanine, acetate, citrate and glucose were quantitated using standard addition methods. Apart from valine and citrate, a general diminution in the concentration of each of these species was found, especially glucose, in the diabetic group. The abnormally low glucose levels in the diabetic group are suggestive of infection in the patient group. However, the depressed lactate levels in the diabetic group suggest that in these cases the fetus was not subjected to stress.