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H-1 nmr as a non-invasive probe of amniotic fluid in insulin dependant diabetes mellitus

McGowan, P.E. and Lawrie, W.C. and Reglinski, J. and Spickett, C.M. and Wilson, R. and Walker, J.J. and Wisdom, S. and MacLean, M.A. (1999) H-1 nmr as a non-invasive probe of amniotic fluid in insulin dependant diabetes mellitus. Journal of Perinatal Medicine, 27 (5). pp. 404-408.

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Abstract

Ten amniotic fluid samples obtained from third trimester pregnant women suffering from insulin dependant diabetes mellitus were analysed by 1H-NMR and compared to ten samples from a group of normal volunteers. A subset of the metabolites identified; valine, lactate, alanine, acetate, citrate and glucose were quantitated using standard addition methods. Apart from valine and citrate, a general diminution in the concentration of each of these species was found, especially glucose, in the diabetic group. The abnormally low glucose levels in the diabetic group are suggestive of infection in the patient group. However, the depressed lactate levels in the diabetic group suggest that in these cases the fetus was not subjected to stress.

Item type: Article
ID code: 17509
Keywords: amniotic fluid, NMR, quantitation, diabetic pregnancy, Chemistry, Pediatrics, Perinatology, and Child Health, Obstetrics and Gynaecology
Subjects: Science > Chemistry
Department: Faculty of Science > Pure and Applied Chemistry
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
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Depositing user: Strathprints Administrator
Date Deposited: 22 Apr 2010 09:54
Last modified: 05 Sep 2014 01:04
URI: http://strathprints.strath.ac.uk/id/eprint/17509

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