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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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H-1 nmr as a non-invasive probe of amniotic fluid in insulin dependant diabetes mellitus

McGowan, P.E. and Lawrie, W.C. and Reglinski, J. and Spickett, C.M. and Wilson, R. and Walker, J.J. and Wisdom, S. and MacLean, M.A. (1999) H-1 nmr as a non-invasive probe of amniotic fluid in insulin dependant diabetes mellitus. Journal of Perinatal Medicine, 27 (5). pp. 404-408.

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Abstract

Ten amniotic fluid samples obtained from third trimester pregnant women suffering from insulin dependant diabetes mellitus were analysed by 1H-NMR and compared to ten samples from a group of normal volunteers. A subset of the metabolites identified; valine, lactate, alanine, acetate, citrate and glucose were quantitated using standard addition methods. Apart from valine and citrate, a general diminution in the concentration of each of these species was found, especially glucose, in the diabetic group. The abnormally low glucose levels in the diabetic group are suggestive of infection in the patient group. However, the depressed lactate levels in the diabetic group suggest that in these cases the fetus was not subjected to stress.