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The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including by researchers from the Department of Computer & Information Sciences involved in mathematically structured programming, similarity and metric search, computer security, software systems, combinatronics and digital health.

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H-1 nmr as a non-invasive probe of amniotic fluid in insulin dependant diabetes mellitus

McGowan, P.E. and Lawrie, W.C. and Reglinski, J. and Spickett, C.M. and Wilson, R. and Walker, J.J. and Wisdom, S. and MacLean, M.A. (1999) H-1 nmr as a non-invasive probe of amniotic fluid in insulin dependant diabetes mellitus. Journal of Perinatal Medicine, 27 (5). pp. 404-408.

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Abstract

Ten amniotic fluid samples obtained from third trimester pregnant women suffering from insulin dependant diabetes mellitus were analysed by 1H-NMR and compared to ten samples from a group of normal volunteers. A subset of the metabolites identified; valine, lactate, alanine, acetate, citrate and glucose were quantitated using standard addition methods. Apart from valine and citrate, a general diminution in the concentration of each of these species was found, especially glucose, in the diabetic group. The abnormally low glucose levels in the diabetic group are suggestive of infection in the patient group. However, the depressed lactate levels in the diabetic group suggest that in these cases the fetus was not subjected to stress.