McGowan, P.E. and Lawrie, W.C. and Reglinski, J. and Spickett, C.M. and Wilson, R. and Walker, J.J. and Wisdom, S. and MacLean, M.A. (1999) H-1 nmr as a non-invasive probe of amniotic fluid in insulin dependant diabetes mellitus. Journal of Perinatal Medicine, 27 (5). pp. 404-408.
Full text not available in this repository. (Request a copy from the Strathclyde author)Abstract
Ten amniotic fluid samples obtained from third trimester pregnant women suffering from insulin dependant diabetes mellitus were analysed by 1H-NMR and compared to ten samples from a group of normal volunteers. A subset of the metabolites identified; valine, lactate, alanine, acetate, citrate and glucose were quantitated using standard addition methods. Apart from valine and citrate, a general diminution in the concentration of each of these species was found, especially glucose, in the diabetic group. The abnormally low glucose levels in the diabetic group are suggestive of infection in the patient group. However, the depressed lactate levels in the diabetic group suggest that in these cases the fetus was not subjected to stress.
| Item type: | Article |
|---|---|
| ID code: | 17509 |
| Keywords: | amniotic fluid, NMR, quantitation, diabetic pregnancy, Chemistry |
| Subjects: | Science > Chemistry |
| Department: | Faculty of Science > Pure and Applied Chemistry Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
| Related URLs: | |
| Depositing user: | Strathprints Administrator |
| Date Deposited: | 22 Apr 2010 09:54 |
| Last modified: | 04 Oct 2012 12:57 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/17509 |
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