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The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including by researchers from the Department of Computer & Information Sciences involved in mathematically structured programming, similarity and metric search, computer security, software systems, combinatronics and digital health.

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Sensing metabolites using donor-acceptor nanodistributions in fluorescence resonance energy transfer

Rolinski, O.J. and Birch, D.J.S. and McCartney, L.J. and Pickup, J.C. (2001) Sensing metabolites using donor-acceptor nanodistributions in fluorescence resonance energy transfer. Applied Physics Letters, 78 (18). pp. 2796-2798. ISSN 0003-6951

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Abstract

Before fluorescence sensing techniques can be applied to media as delicate and complicated as human tissue, an adequate interpretation of the measured observables is required, i.e., an inverse problem needs to be solved. Recently we have solved the inverse problem relating to the kinetics of fluorescence resonance energy transfer (FRET), which clears the way for the determination of the donor-acceptor distribution function in FRET assays. In this letter this approach to monitoring metabolic processes is highlighted and the application to glucose sensing demonstrated.