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A continuum model of the within-animal population dynamics of E-coli O157

Wood, J.C. and Speirs, D.C. and Naylor, S.W. and Gettinby, G. and McKendrick, I.J. (2006) A continuum model of the within-animal population dynamics of E-coli O157. Journal of Biological Systems, 14 (3). pp. 425-443. ISSN 0218-3390

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Abstract

The high level of human morbidity caused by E. coli O157:H7 necessitates an improved understanding of the infection dynamics of this bacterium within the bovine reservoir. Until recently, a degree of uncertainty surrounded the issue of whether these bacteria colonize the bovine gut and as yet, only incomplete in-vivo datasets are available. Such data typically consist of bacterial counts from fecal samples. The development of a deterministic model, which has been devised to make good use of such data, is presented. A partial differential equation, which includes advection, diffusion and growth terms, is used to model the (unobserved) passage of bacteria through the bovine gut. A set of experimentally-obtained fecal count data is used to parameterize the model. Between-animal variability is found to be greater than between-strain variability, with some results adding further weight to the hypothesis that E. coli O157:H7 can colonize the bovine gastrointestinal tract.

Item type: Article
ID code: 17213
Keywords: advection-diffusion equation, method of lines, triangular distribution, maximum likelihood, E. coli O157, Probabilities. Mathematical statistics, Biology
Subjects: Science > Mathematics > Probabilities. Mathematical statistics
Science > Natural history > Biology
Department: Faculty of Science > Mathematics and Statistics
Unknown Department
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 06 Apr 2010 15:15
    Last modified: 12 Mar 2012 11:07
    URI: http://strathprints.strath.ac.uk/id/eprint/17213

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