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Oxidised phospholipid regulation of toll-like receptor signalling

Erridge, Clett and Spickett, C.M. (2007) Oxidised phospholipid regulation of toll-like receptor signalling. Redox Report, 12 (1-2). pp. 76-80. ISSN 1351-0002

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Abstract

Toll-like receptors (TLRs) serve to initiate inflammatory signalling in response to the detection of conserved microbial molecules or products of host tissue damage. Recent evidence suggests that TLR-signalling plays a considerable role in a number of inflammatory diseases, including atherosclerosis and arthritis. Agents which modulate TLR-signalling are, therefore, receiving interest in terms of their potential to modify inflammatory disease processes. One such family of molecules, the oxidised phospholipids (OxPLs), which are formed as a result of inflammatory events and accumulate at sites of chronic inflammation, have been shown to modulate TLR-signalling in both in vitro and in vivo systems. As the interaction between OxPLs and TLRs may play a significant role in chronic inflammatory disease processes, consideration is given in this review to the potential role of OxPLs in the regulation of TLR-signalling.

Item type: Article
ID code: 17181
Keywords: toll-like receptor, signalling, oxidised phospholipids, atherosclerosis, arthritis, Internal medicine, Medicine(all)
Subjects: Medicine > Internal medicine
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 30 Apr 2010 16:41
    Last modified: 05 Sep 2014 01:37
    URI: http://strathprints.strath.ac.uk/id/eprint/17181

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