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Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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Oxygen uptake kinetics measured at the onset of comfortable self-paced walking in elderly women after hip fracture

Fitzsimons, Claire and Simpson, Hamish and Young, Archie and Greig, Carolyn (2007) Oxygen uptake kinetics measured at the onset of comfortable self-paced walking in elderly women after hip fracture. European Journal of Applied Physiology and Occupational Physiology, 100 (3). pp. 355-362. ISSN 1439-6319

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Abstract

The objectives of this study were to (1) evaluate the suitability of 'comfortable' self-paced walking as a mode of exercise to study VO2 kinetics, and (2) to investigate VO2 kinetics after hip fracture using self-paced walking as the exercise mode. The study took place in a Scottish rehabilitation hospital physiotherapy gymnasium [hip fracture (HF) group] and a Scottish University Gymnasium [young (Y) and healthy elderly (HE) groups]. Fifteen women after HF (median age 81 years) and five Y and five older HE women (median ages 22 and 78 years, respectively) took part in the study. Volunteers completed three repeats of 3 min of 'comfortable' self-paced walking on two occasions. The ensemble averaged VO2 response from walks 2 and 3 on visits 1 and 2 were combined and characterised using nonlinear regression techniques to derive a Mean Response Time (MRT). Self-paced walking was described as 'constant-load' exercise (coefficient of variation of lap speeds of ≤6%) in 13 of 15 cases in the HF group on at least one visit (100% of cases in Y and HE groups). Steady-state VO2 was achieved in 3 min in 8 of HF group on Visit 1 and 10 on Visit 2 (100% of cases in Y and HE groups). MRTs for the HF group (51 s, N = 5, 4 repeats; N = 7, 2 repeats) were significantly higher than the Y and HE groups [Y group 22 s (N = 5, 4 repeats); HE group 36 s (N = 5, 4 repeats)]. Self-paced walking provided a suitable mode of exercise to investigate VO2 kinetics in frail older women after HF and permitted the first characterisation of VO2 kinetics in this patient group. This test provides a promising methodology to evaluate rehabilitation efforts in frail individuals.