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Toward single-metal-ion sensing by forster resonance energy transfer

Sutter, J.U. and Macmillan, A.M. and Birch, D.J.S. and Rolinski, O.J. (2008) Toward single-metal-ion sensing by forster resonance energy transfer. Annals of the New York Academy of Sciences, 1130. pp. 62-67. ISSN 0077-8923

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Abstract

Here we describe progress toward our objective of detecting single nonfluorescent hydrated metal ions. Single-ion detection represents detection and spectroscopy at the ultimate sensitivity level of approximately 1.6 x 10(-24) M. Achieving this goal would provide a breakthrough in analytical science and allow much more detailed insight into sensor-ion interaction than that available with conventional bulk detection methods. We combine recent advances in confocal microscopy with the sensitivity and the noninvasive nature of fluorescence by analyzing Forster resonance energy transfer between sensor fluorophores and transition metal ions.

Item type: Article
ID code: 17059
Notes: Document Type: Proceedings Paper
Keywords: ion sensing, Forster resonance energy transfer (FRET), quantum dots, Physics, Biochemistry, Genetics and Molecular Biology(all)
Subjects: Science > Physics
Department: Faculty of Science > Physics
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 21 Apr 2010 13:00
    Last modified: 28 Mar 2014 05:15
    URI: http://strathprints.strath.ac.uk/id/eprint/17059

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