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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including those from the School of Psychological Sciences & Health - but also papers by researchers based within the Faculties of Science, Engineering, Humanities & Social Sciences, and from the Strathclyde Business School.

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Toward single-metal-ion sensing by forster resonance energy transfer

Sutter, J.U. and Macmillan, A.M. and Birch, D.J.S. and Rolinski, O.J. (2008) Toward single-metal-ion sensing by forster resonance energy transfer. Annals of the New York Academy of Sciences, 1130. pp. 62-67. ISSN 0077-8923

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Abstract

Here we describe progress toward our objective of detecting single nonfluorescent hydrated metal ions. Single-ion detection represents detection and spectroscopy at the ultimate sensitivity level of approximately 1.6 x 10(-24) M. Achieving this goal would provide a breakthrough in analytical science and allow much more detailed insight into sensor-ion interaction than that available with conventional bulk detection methods. We combine recent advances in confocal microscopy with the sensitivity and the noninvasive nature of fluorescence by analyzing Forster resonance energy transfer between sensor fluorophores and transition metal ions.