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Imaging inflammation in real time-future of nanoparticles

Hueber, A.J. and Stevenson, R. and Stokes, R.J. and Graham, D. and Garside, P. and McInnes, I.B. (2009) Imaging inflammation in real time-future of nanoparticles. Autoimmunity, 42 (4). pp. 368-372. ISSN 0891-6934

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Abstract

The detection of subclinical early inflammation in autoimmune diseases is an important but currently technically demanding approach to direct initial diagnosis and subsequent choice of therapy. Recent advances in imaging using NP provides the potential to detect cellular recruitment, vascular activation or leakage at a subclinically stage of disease and may provide predictive 'biomarkers' of future pathogenesis. The NP used are either untargeted and taken up by phagocytic cells, or are linked to a ligand, targeting localisation to the site of inflammation. Techniques, varying from MRI and fluorescence to Raman spectroscopy are being employed. In this short review, we summarise many of the recent developments in the field of NP imaging related to inflammation.

Item type: Article
ID code: 16924
Keywords: nanoparticles, NP, inflammation, in vivo imaging, autoimmune disease, Chemistry, Immunology, Immunology, Immunology and Allergy
Subjects: Science > Chemistry
Science > Microbiology > Immunology
Department: Faculty of Science > Pure and Applied Chemistry
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences > Centre for Biophotonics
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 14 Apr 2010 16:00
    Last modified: 28 Mar 2014 05:19
    URI: http://strathprints.strath.ac.uk/id/eprint/16924

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