Strathprints logo
Strathprints Home | Open Access | Browse | Search | User area | Copyright | Help | Library Home | SUPrimo

Effect of improved home ventilation on asthma control and house dust mite allergen levels

Wright, G.R. and Howieson, S.G. and McSharry, C. and McMahon, A.D. and Chaudhuri, R. and Thompson, J. and Donnelly, I. and Brooks, R.G. and Lawson, Alan and Jolly, L. and McAlpine, L. and King, E.M. and Chapman, M.D. and Wood, S. and Thomson, N.C. (2009) Effect of improved home ventilation on asthma control and house dust mite allergen levels. Allergy, 64 (11). pp. 1671-1680. ISSN 0105-4538

[img]
Preview
PDF - Draft Version
Download (210Kb) | Preview

    Abstract

    The warm, humid environment in modern homes favours the dust mite population, but the effect of improved home ventilation on asthma control has not been established. We tested the hypothesis that a domestic mechanical heat recovery ventilation system (MHRV), in addition to allergen avoidance measures, can improve asthma control by attenuating re-colonization rates. We conducted a randomized double-blind placebo-controlled parallel group trial of the installation of MHRV activated in half the homes of 120 adults with asthma, allergic to Dermatophagoides pteronyssinus. All homes had carpets steam cleaned and new bedding and mattress covers at baseline. The primary outcome was morning peak expiratory flow (PEF) at 12 months. At 12 months, the primary end-point; change in mean morning PEF as compared with baseline, did not differ between the MHRV group and the control group (mean difference 13.5 l/min, 95% CI: −2.6 to 29.8, P = 0.10). However, a secondary end-point; evening mean PEF, was significantly improved in the MHRV group (mean difference 24.5 l/min, 95% CI: 8.9-40.1, P = 0.002). Indoor relative humidity was reduced in MHRV homes, but there was no difference between the groups in Der p 1 levels, compared with baseline. The addition of MHRV to house dust mite eradication strategies did not achieve a reduction in mite allergen levels, but did improve evening PEF.

    Item type: Article
    ID code: 16900
    Notes: Strathprints' policy is to record up to 8 authors per publication, plus any additional authors based at the University of Strathclyde. More authors may be listed on the official publication than appear in the Strathprints' record.
    Keywords: asthma, clinical trial, house dust mite, placebo-controlled, ventilation, Immunology, Immunology, Immunology and Allergy
    Subjects: Science > Microbiology > Immunology
    Department: Faculty of Engineering > Architecture
    Strathclyde Business School > Management Science
    Related URLs:
      Depositing user: Strathprints Administrator
      Date Deposited: 25 Mar 2010 12:19
      Last modified: 06 Sep 2014 00:25
      URI: http://strathprints.strath.ac.uk/id/eprint/16900

      Actions (login required)

      View Item

      Fulltext Downloads: