Picture of person typing on laptop with programming code visible on the laptop screen

World class computing and information science research at Strathclyde...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including by researchers from the Department of Computer & Information Sciences involved in mathematically structured programming, similarity and metric search, computer security, software systems, combinatronics and digital health.

The Department also includes the iSchool Research Group, which performs leading research into socio-technical phenomena and topics such as information retrieval and information seeking behaviour.

Explore

Resonance raman-spectroscopy of hemoglobin in intact-cells: A probe of oxygen-uptake by erythrocytes in rheumatoid arthritis

Hoey, S. and Brown, D.H. and McConnell, A.A. and Smith, W.E. and Marabani, M. and Sturrock, R.D. (1988) Resonance raman-spectroscopy of hemoglobin in intact-cells: A probe of oxygen-uptake by erythrocytes in rheumatoid arthritis. Journal of Inorganic Biochemistry, 34 (3). pp. 189-199. ISSN 0162-0134

Full text not available in this repository. Request a copy from the Strathclyde author

Abstract

Resonance Raman spectra from intact viable erythrocytes can be used to study oxygen uptake in solution. In addition to changes in the oxidation state marker (v4), other bands due to the porphyrin ring (v3) and vinyl modes indicate subtle changes at oxygen pressures close to where the T/R change occurs. A comparison of whole cell and lysate spectra indicates a partial denaturation of hemoglobin on lysis. A simple smear technique is used to measure spectra from rheumatoid and normal blood. Results indicate a faster but less complete uptake of oxygen in cells from patients with rheumatoid arthritis than is the case in normal cell populations.