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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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Multiple-timescale photoreactivity of a model compound related to the active site of [fefe]-hydrogenase

Ridley, A.R. and Stewart, A. and Adamczyk, K. and Ghosh, H.N. and Kerkeni, B. and Guo, Z.X. and Nibbering, E.T.J. and Pickett, C.J. and Hunt, Neil T. (2008) Multiple-timescale photoreactivity of a model compound related to the active site of [fefe]-hydrogenase. Inorganic Chemistry, 47 (17). pp. 7453-7455. ISSN 0020-1669

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Abstract

Ultraviolet (UV) photolysis of (mu-S(CH2)(3)S)Fe-2(CO)(6) (1), a model compound of the Fe-hydrogenase enzyme system, has been carried out. When ultrafast UV-pump infrared (IR)-probe spectroscopy, steady-state Fourier transform IR spectroscopic methods, and density functional theory simulations are employed, it has been determined that irradiation of I in an alkane solution at 350 nm leads to the formation of two isomers of the 16-electron complex (mu-S(CH2)(3)S)Fe-2(CO)(5) within 50 ps with evidence of a weakly associated solvent adduct complex. 1 is subsequently recovered on timescales covering several minutes. These studies constitute the first attempt to study the photochemistry and reactivity of these enzyme active site models in solution following carbonyl ligand photolysis.