Strathprints Home | Open Access | Browse | Search | User area | Copyright | Help | Library Home | SUPrimo

Infection frequently triggers thrombotic microangiopathy in patients with preexisting risk factors: a single-institution experience

Douglas, K.W. and Pollock, K.G.J. and Young, D. and Catlow, J. and Green, R. (2010) Infection frequently triggers thrombotic microangiopathy in patients with preexisting risk factors: a single-institution experience. Journal of Clinical Apheresis, 25 (2). pp. 47-53. ISSN 0733-2459

[img]
Preview
PDF (strathprints016640.pdf)
Download (153Kb) | Preview

    Abstract

    Thrombotic microangiopathies are rare conditions characterized by microangiopathic hemolytic anemia, microthrombi, and multiorgan insult. The disorders, which include hemolytic uremic syndrome and thrombotic thrombocytopenic purpura, are often acute and life threatening. We report a retrospective analysis of 65 patients presenting to our institution from 1997 to 2008 with all forms of thrombotic microangiopathy. Therapeutic plasma exchange was a requirement for analysis and 65 patients were referred to our institution; 66% of patients were female and median age at presentation was 52 years. Bacterial infection was the most commonly identified etiologic factor and in the multivariate model was the only significant variable associated with survival outcome (odds ratio 5.1, 95% confidence interval, 1.2-21.7). As infection can be considered a common trigger event for thrombotic microangiopathy, patients with hepatobiliary sepsis may benefit from elective cholecystectomy. We conclude that bacterial infection frequently triggers TTP and other thrombotic microangiopathies in patients with preexisting risk factors and propose a model for the development of these syndromes.

    Item type: Article
    ID code: 16640
    Keywords: infection, thrombotic thrombocytopenic purpura, thrombotic microangiopathy, hemolytic uremic syndrome, bacterial sepsis, cholelithiasis, Mathematics
    Subjects: Science > Mathematics
    Department: Faculty of Science > Mathematics and Statistics
    Related URLs:
      Depositing user: Mrs Ann Lynch
      Date Deposited: 22 Mar 2010 15:43
      Last modified: 16 Mar 2012 18:46
      URI: http://strathprints.strath.ac.uk/id/eprint/16640

      Actions (login required)

      View Item

      Fulltext Downloads: