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A CMOS time-resolved fluorescence lifetime analysis micro-system

Rae, B.R. and Muir, K.R. and Gong, Z. and McKendry, Jonathan and Girkin, J.M. and Gu, E. and Renshaw, D. and Dawson, M.D. and Henderson, R.K. (2009) A CMOS time-resolved fluorescence lifetime analysis micro-system. Sensors, 9 (11). pp. 9255-9274. ISSN 1424-8220

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We describe a CMOS-based micro-system for time-resolved fluorescence lifetime analysis. It comprises a 16 × 4 array of single-photon avalanche diodes (SPADs) fabricated in 0.35 μm high-voltage CMOS technology with in-pixel time-gated photon counting circuitry and a second device incorporating an 8 × 8 AlInGaN blue micro-pixellated light-emitting diode (micro-LED) array bump-bonded to an equivalent array of LED drivers realized in a standard low-voltage 0.35 μm CMOS technology, capable of producing excitation pulses with a width of 777 ps (FWHM). This system replaces instrumentation based on lasers, photomultiplier tubes, bulk optics and discrete electronics with a PC-based micro-system. Demonstrator lifetime measurements of colloidal quantum dot and Rhodamine samples are presented.