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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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Responses of molecular indicators of exposure in mesocosms: common carp (cyprinus carpio) exposed to the herbicides alachlor and atrazine

Chang, L.W. and Toth, G.P. and Gordon, D.A. and Graham, David W. and Meier, J.R. and Knapp, Charles W. and deNoyelles, Frank and Campbell, S. and Lattier, D.L. (2005) Responses of molecular indicators of exposure in mesocosms: common carp (cyprinus carpio) exposed to the herbicides alachlor and atrazine. Environmental Toxicology and Chemistry, 24 (1). pp. 190-197.

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Abstract

Common carp (Cyprinus carpio) were treated in aquatic mesocosms with a single pulse of the herbicides atrazine or alachlor to study the bioavailability and biological activity of these herbicides using molecular indicators: Liver vitellogenin gene expression in male fish for estrogenic activity, liver cytochrome P4501A1 gene expression, and DNA damage in blood cells using the single-cell gel electrophoresis method. Both alachlor and atrazine showed dose-related increases in DNA strand breaks at environmentally relevant concentrations (<100 ppb). Gene expression indicators showed that neither herbicide had estrogenic activity in the carp, whereas atrazine at concentrations as low as 7 ppb induced cytochrome P4501A1 These results support the study of molecular indicators for exposure in surrogate ecosystems to gauge relevant environmental changes following herbicide treatments.