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Changes in connectivity profiles define functionally-distinct regions in human medial frontal cortex

Johansen-Berg, H. and Behrens, T.E.J. and Robson, M.D. and Drobnjak, I. and Rushworth, M.F.S. and Brady, J.M. and Smith, S.M. and Higham, D.J. and Matthews, P.M. (2004) Changes in connectivity profiles define functionally-distinct regions in human medial frontal cortex. Proceedings of the National Academy of Sciences, 101 (26). pp. 13335-13340.

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Abstract

A fundamental issue in neuroscience is the relation between structure and function. However, gross landmarks do not correspond well to microstructural borders and cytoarchitecture cannot be visualized in a living brain used for functional studies. Here, we used diffusion-weighted and functional MRI to test structure-function relations directly. Distinct neocortical regions were defined as volumes having similar connectivity profiles and borders identified where connectivity changed. Without using prior information, we found an abrupt profile change where the border between supplementary motor area (SMA) and pre-SMA is expected. Consistent with this anatomical assignment, putative SMA and pre-SMA connected to motor and prefrontal regions, respectively. Excellent spatial correlations were found between volumes defined by using connectivity alone and volumes activated during tasks designed to involve SMA or pre-SMA selectively. This finding demonstrates a strong relationship between structure and function in medial frontal cortex and offers a strategy for testing such correspondences elsewhere in the brain.

Item type: Article
ID code: 163
Keywords: neuroscience, cytoarchitecture, microstructural borders, connectivity profiles, brain, human brain, Science (General), Human anatomy
Subjects: Science > Science (General)
Science > Human anatomy
Department: Faculty of Science > Mathematics and Statistics
Related URLs:
Depositing user: Ms Sarah Scott
Date Deposited: 21 Feb 2006
Last modified: 12 Mar 2012 10:35
URI: http://strathprints.strath.ac.uk/id/eprint/163

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