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A study of the relative importance of lipophilic, π-π and dipole-dipole interactions on cyanopropyl, phenyl and alkyl LC phases bonded onto the same base silica

Markopoulou, Catherine and Tweedle, Tracey and Watson, D.G. and Skellern, G.G. and Reda, Houssam and Petersson, Patrik and Bradstock, Hannah and Euerby, Melvin R. (2009) A study of the relative importance of lipophilic, π-π and dipole-dipole interactions on cyanopropyl, phenyl and alkyl LC phases bonded onto the same base silica. Chromatographia, 70 (5-6). pp. 705-715. ISSN 0009-5893

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Abstract

Cyano (CN), butyl (C4), phenyl and octadecyl (C18) phases prepared from the same base silica gel were chromatographically characterized in order to assess the relative importance of lipophilic, π-π and dipole-dipole interactions in governing retention on these differing phases. Dipole interactions of analytes (possessing dipole moments and low lipophilicity) with CN phases were primarily responsible for the elution order. However, as the analytes' lipophilicity increased, the lipophilic interaction predominated over the dipole interaction. In comparison, retention on the phenyl phase appeared to be complex, being controlled by a mixture of lipophilic, π-π and dipole-dipole interactions. Retention on the C4 and C18 phases was dictated by the analyte's lipophilicity and its accessibility into the phase.

Item type: Article
ID code: 16016
Keywords: column liquid chromatography, retention behaviour and phase stability, lipophilic interactions, π–π interactions, dipole–dipole interactions, cyano phenyl and alkyl phases, Therapeutics. Pharmacology, Pharmacy and materia medica, Microbiology, Biochemistry, Organic Chemistry, Analytical Chemistry, Clinical Biochemistry
Subjects: Medicine > Therapeutics. Pharmacology
Medicine > Pharmacy and materia medica
Science > Microbiology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
Depositing user: Ms Ann Barker-Myles
Date Deposited: 10 Mar 2010 17:42
Last modified: 05 Sep 2014 03:53
URI: http://strathprints.strath.ac.uk/id/eprint/16016

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