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Inhibitor of cysteine peptidase does not influence the development of Leishmania mexicana in Lutzomyia longipalpis

Jecna, Lucie and Svarovska, Anna and Besteiro, Sébastien and Mottram, Jeremy C. and Coombs, Graham H. and Volf, Petr (2009) Inhibitor of cysteine peptidase does not influence the development of Leishmania mexicana in Lutzomyia longipalpis. Journal of Entomology, 46 (3). pp. 605-609. ISSN 0022-2585

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Abstract

It has been proposed that the natural cysteine peptidase inhibitor ICP of Leishmania mexicana protects the protozoan parasite from insect host proteolytic enzymes, thereby promoting survival. To test this hypothesis, L. mexicana mutants deficient in ICP were evaluated for their ability to develop in the sand fly Lutzomyia longipalpis. No significant differences were found between the wild-type parasites, two independently derived ICP-deficient mutants, or mutants overexpressing ICP; all lines developed similarly in the sand fly midgut and produced heavy late-stage infections. In addition, recombinant L. mexicana ICP did not inhibit peptidase activity of the midgut extracts in vitro. We conclude that ICP has no major role in promoting survival of L. mexicana in the vectorial part of its life cycle in L. longipalpis.

Item type: Article
ID code: 15324
Keywords: sand fly, leishmania, phlebotomus, cysteine peptidase, Therapeutics. Pharmacology, Pharmacy and materia medica, Microbiology
Subjects: Medicine > Therapeutics. Pharmacology
Medicine > Pharmacy and materia medica
Science > Microbiology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
Depositing user: Ms Ann Barker-Myles
Date Deposited: 05 Feb 2010 16:46
Last modified: 12 Mar 2012 11:01
URI: http://strathprints.strath.ac.uk/id/eprint/15324

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