Strathprints logo
Strathprints Home | Open Access | Browse | Search | User area | Copyright | Help | Library Home | SUPrimo

Formation of valine microcrystals through rapid antisolvent precipitation

Variny, Miroslav and Alvarez de Miguel, Sandra and Moore, Barry D. and Sefcik, Jan (2008) Formation of valine microcrystals through rapid antisolvent precipitation. Journal of Dispersion Science and Technology, 29 (4). pp. 617-620. ISSN 0193-2691

This is the latest version of this item.

[img]
Preview
PDF (strathprints015031.pdf)
Download (84Kb) | Preview

    Abstract

    In this work we have experimentally studied concentration effects on antisolvent precipitation of valine (an amino acid) from aqueous isopropanol solutions. Our experiments showed that the valine precipitation is very sensitive to both the supersaturation and to the water content in the final solution. Results from spectrophotometric measurements and supersaturation analysis showed that the crystal formation kinetics are strongly dependent on both mixing and concentration profiles in the early stages of the process, even though no visible change in the systems occurs immediately upon mixing with the antisolvent or subsequent dilution. Results from small-angle static light scattering measurements showed that the first visible crystals are of micron size and they grow only little over time, while their number increases gradually. Taken together, these experiments point to intermediate phase separation of (possible amorphous) precursors, being either very small nanoparticles or droplets with their refractive index closely matching that of the continuous phase, which subsequently assemble into micron size valine crystals.

    Item type: Article
    ID code: 15031
    Keywords: antisolvent crystallization, valine, isopropanol, light scattering, Chemical engineering, Chemistry, Polymers and Plastics, Surfaces, Coatings and Films, Physical and Theoretical Chemistry
    Subjects: Technology > Chemical engineering
    Science > Chemistry
    Department: Faculty of Engineering > Chemical and Process Engineering
    Unknown Department
    Faculty of Science > Pure and Applied Chemistry
    Related URLs:
      Depositing user: Dr Jan Sefcik
      Date Deposited: 19 Feb 2010 14:24
      Last modified: 05 Sep 2014 13:23
      URI: http://strathprints.strath.ac.uk/id/eprint/15031

      Available Versions of this Item

      • Formation of valine microcrystals through rapid antisolvent precipitation. (deposited 19 Feb 2010 14:24)[Currently Displayed]

      Actions (login required)

      View Item

      Fulltext Downloads: