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The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the Physical Activity for Health Group based within the School of Psychological Sciences & Health. Research here seeks to better understand how and why physical activity improves health, gain a better understanding of the amount, intensity, and type of physical activity needed for health benefits, and evaluate the effect of interventions to promote physical activity.

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Dynamic sensitivity and oscillation analysis of signal transduction networks

Jia, J.F. and Yue, H. (2010) Dynamic sensitivity and oscillation analysis of signal transduction networks. Journal of Sichuan University: Engineering Science Division, 42 (2). pp. 171-176. ISSN 1009-3087

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Abstract

In order to understand the complexity of cellular signaling pathways as nonlinear autonomous systems, their regulation mechanisms and robustness properties, the system dynamic characteristics of cellular networks were analyzed using perspectives of engineering and information sciences. Taking the NF-κB signaling transduction networks as an example , dynamic sensitivity analysis, nonlinear dynamic analysis were explored to study the parametric sensitivities and oscillation patterns with respect to the system output of cell signal transduction networks. The simulation results demonstrated that the output signal NF-κBn is relatively sensitive to eight key rate constants and the oscillation behavior of NF-κBn is obviously affected by the negative feedback function of IKK.