Strathprints Home | Open Access | Browse | Search | User area | Copyright | Help | Library Home | SUPrimo

Dynamic sensitivity and oscillation analysis of signal transduction networks

Jia, J.F. and Yue, H. (2010) Dynamic sensitivity and oscillation analysis of signal transduction networks. Journal of Sichuan University: Engineering Science Division, 42 (2). pp. 171-176. ISSN 1009-3087

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

In order to understand the complexity of cellular signaling pathways as nonlinear autonomous systems, their regulation mechanisms and robustness properties, the system dynamic characteristics of cellular networks were analyzed using perspectives of engineering and information sciences. Taking the NF-κB signaling transduction networks as an example , dynamic sensitivity analysis, nonlinear dynamic analysis were explored to study the parametric sensitivities and oscillation patterns with respect to the system output of cell signal transduction networks. The simulation results demonstrated that the output signal NF-κBn is relatively sensitive to eight key rate constants and the oscillation behavior of NF-κBn is obviously affected by the negative feedback function of IKK.

Item type: Article
ID code: 14749
Keywords: signal transduction networks, dynamic sensitivity analysis, oscillation, limit cycle, negative feedback, Electrical engineering. Electronics Nuclear engineering
Subjects: Technology > Electrical engineering. Electronics Nuclear engineering
Department: Faculty of Engineering > Electronic and Electrical Engineering
Related URLs:
Depositing user: Strathprints Administrator
Date Deposited: 15 Jun 2010 15:20
Last modified: 16 Jul 2013 23:32
URI: http://strathprints.strath.ac.uk/id/eprint/14749

Actions (login required)

View Item