Jia, J.F. and Yue, H. (2008) Model reduction of a signalling transduction pathway based on global sensitivity analysis. Communications of SIWN, 3. pp. 102-106. ISSN 1757-4439Full text not available in this repository. (Request a copy from the Strathclyde author)
A model reduction method based on global sensitivity analysis (GSA) is proposed in this paper and applied to the IκBα-NF-κB signalling transduction pathway network. This approach uses the modified Morris method to analyze the global parametric sensitivities. According to the results of global sensitivities, the number of the biological reactions is reduced by eliminating those reactions that are identified to be insensitive. Simulation results demonstrate that the output prediction of the simplified model is very close to that of the original model.
|Keywords:||model reduction, global sensitivity analysis, morris method, signalling pathway network, Electrical engineering. Electronics Nuclear engineering|
|Subjects:||Technology > Electrical engineering. Electronics Nuclear engineering|
|Department:||Faculty of Engineering > Electronic and Electrical Engineering|
|Depositing user:||Strathprints Administrator|
|Date Deposited:||08 Jul 2010 09:20|
|Last modified:||29 Apr 2016 11:38|