Picture of virus under microscope

Research under the microscope...

The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

Explore SIPBS research

Predictors of upper limb recovery following stroke: a systematic review

Coupar, F. and Langhorne, P. and Rowe, P.J. and Weir, C. (2008) Predictors of upper limb recovery following stroke: a systematic review. In: European Stroke Conference, 2008-05-16.

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

Background: Upper limb hemiparesis is a common, persisting and disabling sequela of stroke. However, evidence for the effectiveness of interventions targeted at the upper limb remains inconclusive. Identification of reliable predictors of upper limb recovery would allow interventions to be better targeted at appropriate patients and thus potentially optimise upper limb rehabilitation. We carried out a systematic review of predictors of upper limb recovery. Methods: We completed searches in Medline, Embase, Amed, Cinahl and Cochrane CENTRAL databases. Articles were included if predictor variables were measured at baseline and related to an outcome of upper limb recovery at a future time point. Exclusion criteria included predictor variables relating to a particular treatment and outcome measurements of very specific upper limb impairments such as spasticity or pain. Results: To date two independent reviewers have identified 54 studies (over 6000 participants) that meet the inclusion criteria. Predictor variables which have been considered within these studies include; age, sex, lesion site, initial motor impairment, motor evoked potentials and somatosensory evoked potentials. Preliminary results indicate that the severity of the initial upper limb impairment is the most consistently reported and significant predictor of upper limb recovery. Discussion: Interpretation of these results is complicated by methodological factors including variations in study populations, upper limb motor outcome scales, timing of baseline and outcome assessments and predictors selected. The most important predictive factor for upper limb recovery following stroke appears to be the initial severity of motor impairment. This paper was presented at the XVII European Stroke Conference in 2009.