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Clinical surveillance of thrombotic microangiopathies in Scotland, 2003-2005

Pollock, K.G.J. and Young, D. and Beattie, T.J. and Todd, W.T.A. (2008) Clinical surveillance of thrombotic microangiopathies in Scotland, 2003-2005. Infection and Epidemiology, 136 (1). pp. 115-121. ISSN 0950-2688

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    Abstract

    The prevalence, incidence and outcomes of haemolytic uraemic syndrome (HUS) and thrombotic thrombocytopaenic purpura (TTP) are not well established in adults or children from prospective studies. We sought to identify both outcomes and current management strategies using prospective, national surveillance of HUS and TTP, from 2003 to 2005 inclusive. We also investigated the links between these disorders and factors implicated in the aetiology of HUS and TTP including infections, chemotherapy, and immunosuppression. Most cases of HUS were caused by verocytotoxin-producing Escherichia coli (VTEC), of which serotype O157 predominated, although other serotypes were identified. The list of predisposing factors for TTP was more varied although use of immunosuppressive agents and severe sepsis, were the most frequent precipitants. The study demonstrates that while differentiating between HUS and TTP is sometimes difficult, in most cases the two syndromes have quite different predisposing factors and clinical parameters, enabling clinical and epidemiological profiling for these disorders.

    Item type: Article
    ID code: 14371
    Keywords: thrombotic microangiopathies, Scotland, haemolytic uraemic syndrome, thrombotic thrombocytopaenic purpura, HUS, TTP, Mathematics, Microbiology, Infectious Diseases, Epidemiology
    Subjects: Science > Mathematics
    Science > Microbiology
    Department: Faculty of Science > Mathematics and Statistics
    Related URLs:
      Depositing user: Mrs Ann Lynch
      Date Deposited: 13 Jan 2010 18:19
      Last modified: 05 Sep 2014 00:21
      URI: http://strathprints.strath.ac.uk/id/eprint/14371

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