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The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the Physical Activity for Health Group based within the School of Psychological Sciences & Health. Research here seeks to better understand how and why physical activity improves health, gain a better understanding of the amount, intensity, and type of physical activity needed for health benefits, and evaluate the effect of interventions to promote physical activity.

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STS blood conservation guidelines: the role of leukocyte filtration

Gourlay, T. and Olivencia-Yurvati, A.H. and Gunaydin, S. (2008) STS blood conservation guidelines: the role of leukocyte filtration. Annals of Thoracic Surgery, 85 (3). pp. 1138-1139. ISSN 0003-4975

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Abstract

The inference that neutrophils trapped by leukocyte filters may exacerbate inflammatory mechanisms is not new, and this has been widely discussed in the clinical world. This suggestion stems from the work of Scholz and colleagues [3] who observed that leukocyte filtration failed to limit neutrophil stimulation and augmented polymorphonuclear leukocyte elastase levels. Although some have tried to argue that increasing the circulating elastase may break down the structural protein elastin that holds endothelial cells together, and in this way may worsen clinical outcome, critically, the authors in this particular study noted that "we did not find clinical disadvantages related to any filtration strategy tested." This conclusion supports our belief that the assay used to measure elastase can not distinguish between active and inactive elastase. Therefore, the functional significance of having elevated elastase levels, as measured by the available technology, is not really known.