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Differential effect of substrate stiffness and adsorbed fibronectin density on vascular smooth muscle migration rate

Whitton, A. and Flint, D.J. and Black, R.A. (2009) Differential effect of substrate stiffness and adsorbed fibronectin density on vascular smooth muscle migration rate. [Proceedings Paper]

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Abstract

Current surgical approaches to the treatment of patients with cardiovascular disease include the implantation of devices that aim to restore and maintain the flow of blood; however, the patency of such devices in the long term is limited by a physiological process called intimal hyperplasia (IH) or restenosis: the thickening of the vessel wall in response to injury.http://www.ecmjournal.orgThis study aims to investigate the effect of both the stiffness of the implanted material and the concentration of adsorbed proteins from the blood onto the material surface on the migration of the cells resident in the vessel wall; an important early stage in the progression of IH.

Item type: Proceedings Paper
ID code: 13966
Keywords: cardiovascular disease, differential effect, substrate stiffness, adsorbed fibronectin density, vascular smooth muscle migration rate, intimal hyperplasia (IH), restenosis, injury, Bioengineering, Science (General), Engineering (General). Civil engineering (General)
Subjects: Technology > Engineering (General). Civil engineering (General) > Bioengineering
Science > Science (General)
Technology > Engineering (General). Civil engineering (General)
Department: Faculty of Engineering > Bioengineering
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
Depositing user: Ms Ashley Urie
Date Deposited: 16 Dec 2009 15:05
Last modified: 16 Jul 2013 23:12
URI: http://strathprints.strath.ac.uk/id/eprint/13966

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