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Differential effect of substrate stiffness and adsorbed fibronectin density on vascular smooth muscle migration rate

Whitton, A. and Flint, D.J. and Black, R.A. (2009) Differential effect of substrate stiffness and adsorbed fibronectin density on vascular smooth muscle migration rate. European Cells and Materials, 18 (Suppl.). p. 29. ISSN 1473-2262

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Abstract

Current surgical approaches to the treatment of patients with cardiovascular disease include the implantation of devices that aim to restore and maintain the flow of blood; however, the patency of such devices in the long term is limited by a physiological process called intimal hyperplasia (IH) or restenosis: the thickening of the vessel wall in response to injury.http://www.ecmjournal.orgThis study aims to investigate the effect of both the stiffness of the implanted material and the concentration of adsorbed proteins from the blood onto the material surface on the migration of the cells resident in the vessel wall; an important early stage in the progression of IH.