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Structural instability in an autophosphorylating kinase switch

Grinfeld, M. and Webb, S.D. (2009) Structural instability in an autophosphorylating kinase switch. Mathematical Biosciences, 219 (2). pp. 92-96. ISSN 0025-5564

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Abstract

We analyse a simple kinase model that exhibits bistability when there is no protein turnover, and show analytically that the property of being bistable is not necessarily conserved when degradation and synthesis of the kinase are taken into account.