Strathprints Home | Open Access | Browse | Search | User area | Copyright | Help | Library Home | SUPrimo

Response to chronic exposure to hexavalent chromium in human monocytes

Raghunathan, Vijay Krishna and Ellis, E. and Grant, M. Helen (2009) Response to chronic exposure to hexavalent chromium in human monocytes. Toxicology in Vitro, 23 (4). pp. 647-652. ISSN 0887-2333

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

Elevated circulating levels of metal ions, particularly chromium, have been measured in the blood of patients with metal hip implants, and this has lead to concerns about the long term safety of the prostheses. For example, depletion of lymphocytes has been reported in vivo in patients with metallic prostheses, and correlated with elevated chromium and cobalt concentrations in blood. However, the implications for immune function are unclear. We have assessed the in vitro responses of U937 human monocytes to chronic exposure (4 weeks) to Cr (VI) ions at concentrations which have been measured in patients with metal artificial hip implants (0.05-0.5 μM). Chronic exposure to these low clinically relevant concentrations of Cr (VI) induced a potent adaptive response with elevated glutathione-S-transferase (pi) expression and increased activities and expression of reactive oxygen scavengers, superoxide dismutases, catalase and glutathione peroxidase. Such direct toxicity of Cr ions may contribute to the effects of metal implants on lymphocyte populations in vivo.

Item type: Article
ID code: 13270
Keywords: in vitro chromium toxicity, monocytes, metal orthopaedic implants, pharmacology, Therapeutics. Pharmacology, Pharmacy and materia medica, Microbiology, Toxicology
Subjects: Medicine > Therapeutics. Pharmacology
Medicine > Pharmacy and materia medica
Science > Microbiology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Engineering > Bioengineering
Related URLs:
    Depositing user: Ms Ann Barker-Myles
    Date Deposited: 19 Oct 2009 10:34
    Last modified: 04 Sep 2014 23:50
    URI: http://strathprints.strath.ac.uk/id/eprint/13270

    Actions (login required)

    View Item